The Jackson Laboratory

2026 Computational Sciences Publications

2026 Publications:

  1. Ouardouz M, Hernan AE, Mahoney JM, Scott RC. Stimulation of the medial septum diagonal band of broca rescues learning and memory deficits in Fmr1 KO mice. iScience. 2026;29(3):115066. PMID: 41809053; PMCID: PMC12969123. https://libkey.io/libraries/3075/41809053

  2. Durante GL, Tyler AL, Scott RC, Hernan AE, Mahoney JM. Meta-analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape. Epilepsia. 2026;67(3):1421-32. PMID: 41358547; PMCID: PMC13007847. https://libkey.io/libraries/3075/41358547

  3. Yang T, Huhe H, Williams SP, Kaur S, Ay YA, Davis-Gilbert ZW, Cary GA, Paisie C, Butler RR, 3rd, Wiley J, Betarbet R, Fu H, Duong D, Seyfried NT, Leal K, Carter GW, Edwards A, Levey AI, Capener JL, Drewry DH, Hossain MA, Oh HJ, Axtman AD, Sukoff Rizzo SJ, Longo FM, The Emory-Sage-SGC-JAX TREAT-AD Center. PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice. Alzheimers Dement. 2025;21(12):e71033. PMID: 41451871; PMCID: PMC12741935. https://libkey.io/libraries/3075/41451871

  4. Sabnis GS, Hession L, Mahoney JM, Mobley A, Santos M, Geuther B, Kumar V. Visual detection of seizures in mice using supervised machine learning. Cell Rep Methods. 2025;5(12):101242. PMID: 41308647. https://libkey.io/libraries/3075/41308647

  5. Ordaz T, Sundaramurthi JC, Arterbery AS, Bagley AM, Gargano MA, Bauer JP, Danis D, Giampietro P, Raney E, Rekerle L, Shingle M, Davids JR, Robinson PN. An ITPR1 Variant in the IP3-ITPR1 Binding Pocket Associated With a Clinical Phenotype of Athetoid Cerebral Palsy. Am J Med Genet A. 2026;200(2):459-67. PMID: 40968496. https://libkey.io/libraries/3075/40968496

  6. Cary GA, Li Q, Wiley JC, Paisie CA, Du Y, Zoeller EL, Duong D, Fu H, Seyfried NT, Levey AI, Betarbet R, Carter GW, for The Emory-Sage-SGC-JAX TREAT-AD Center. Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets. Alzheimers Dement. 2025;21(12):e71008. PMID: 41388808; PMCID: PMC12701361. https://libkey.io/libraries/3075/41388808

  7. Arnuk A, Han C, Lawal AE, Wang B, Karma S, Zhang Z, Yassouf MY, Rajendran SH, Chandok H, Eller ML, Sajedi S, McKenna M, Herman E, Hagen L, Nadorp B, Mo Z, Orellana H, Tsirigos A, Miura P, Abbas HA, Aifantis I, Wang E. Epigenetic reactivation of the tumor suppressor ZBTB7A by KDM4 inhibition in human acute myeloid leukemia. Sci Transl Med. 2026;18(838):eady2936. PMID: 41739902. https://libkey.io/libraries/3075/41739902

  8. Lindsay H, Du Y, Qi L, Zhang H, Zhao S, Braun FK, Kogiso M, Stephan C, Alton G, Stein G, Beaton G, Kesari S, Neuhauser S, Stearns T, Chuang J, Jocoy EL, Bult CJ, Teicher B, Smith MA, Li XN. Targeting Pediatric Glioblastomas by Combining OLIG2 Inhibitor CT-179 with Fractionated Radiation in a Panel of Patient-Derived Orthotopic Xenograft Mouse Models. Int J Mol Sci. 2026;27(3). PMID: 41683962; PMCID: PMC12898090. https://libkey.io/libraries/3075/41683962

  9. Abdelfattah N, Natarajan S, Tran HN, Wong T, Faisal M, Maldonado J, McMinimy R, Borland H, Chen SH, Zhao H, Vasquez M, Rodriguez FF, Wagner CR, Camargo F, Olson J, George J, Yun K. Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma. Cancer Cell. 2026;44(4):760-76 e8. PMID: 41650973; PMCID: PMC12885226. https://libkey.io/libraries/3075/41650973

  10. Hardy CC, Sheehan S, Mawe S, Sebasco N, Ricke W, Mahoney M, Korstanje R. Spoti-find: a novel, open-source void spot assay image analysis tool. Am J Physiol Renal Physiol. 2026;330(5):F513-F21. PMID: 41874957. https://libkey.io/libraries/3075/41874957

  11. Kaur S, Tyler AL, Durante GL, Cary GA, Carter GW, Mahoney JM. Identifying transcriptomic signatures that mediate the causal effect of genotype on Alzheimer's disease. Front Neurosci. 2026;20:1716828. PMID: 41938695; PMCID: PMC13044590. https://libkey.io/libraries/3075/41938695

  12. Ouardouz M, Hernan AE, Mahoney JM, Scott RC. Auditory Stimulation Rescues Cognitive Deficit in Fmr1-KO Mice. Brain Sci. 2026;16(4):380. PMID: 42041789; PMCID: PMC13114061. https://libkey.io/libraries/3075/42041789

  13. Reese JT, Chimirri L, Bridges Y, Danis D, Caufield JH, Gargano MA, Kroll C, Schmeder A, Liu F, Wissink K, McMurry JA, Graefe ASL, Niyonkuru E, Korn DR, Casiraghi E, Valentini G, Jacobsen JOB, Haendel M, Smedley D, Mungall CJ, Robinson PN. Systematic benchmarking demonstrates large language models have not reached the diagnostic accuracy of traditional rare-disease decision support tools. Eur J Hum Genet. 2026;34(4):498-504. PMID: 41735669; PMCID: PMC13046788. https://libkey.io/libraries/3075/41735669

  14. Cano Achuri MI, Lara MK, Abed Rabbo K, Wilson BT, Meek A, Mahoney JM, Hernan AE, Brockmeier AJ. Interpretable EEG biomarkers for neurological disease models in mice using bag-of-waves classifiers. J Neural Eng. 2026;23(3):036016. PMID: 41780177; PMCID: PMC13093256. https://libkey.io/libraries/3075/41780177

  15. Catozzi S, Sips F, Totis N, Bisotti MA, Stathopoulos S, Torchia M, Emili L, Carbone V, Baker C, Mahoney JM, Röshammar D, on behalf of the Cardioverse Project Team. Drug Safety Assessment Based on Target Affinity, Drug Exposure and Plasma Protein Binding: Drug-Induced Cardiotoxicity from a Translational Pharmacology Perspective. Int J Mol Sci. 2026;27(10):4563. PMID: 42196540; PMCID: PMC13207947. https://libkey.io/libraries/3075/42196540

  16. Courau T, Jaszczak RG, Samad B, Flynn E, Chew NW, Reeder GC, Tsui J, Teklu S, Pass LF, Edwards AW, Naser M, Ray A, Wismer H, Bunis D, Lupin-Jimenez L, Gavil NV, Masopust D, Graham JP, Skelly DA, Vesco X, Liu ET, Fragiadakis GK, Combes AJ, Krummel MF. Differential assembly of mouse and human tumor microenvironments. Nat Immunol. 2026;27(6):1282-93. PMID: 42156893. https://libkey.io/libraries/3075/42156893

  17. Wang Y, Zhang Z, Longo C, Zhang W, Wang Q, Najjar A, Tian X, Lazcano Segura RN, Roth ME, Gill J, Harrison DJ, Xu Z, Yi Y, Zhou X, Jusu S, Stearns TM, Neuhauser SB, Bult CJ, Wang J, Lazar AJ, Gorlick R. Identification of CADM1 as an Immunotherapeutic Target and Evaluation of a Novel CADM1-Targeting Antibody-Drug Conjugate in Preclinical Osteosarcoma Models. Mol Cancer Ther. 2026;25(6):881-96. PMID: 41517891; PMCID: PMC12925509. https://libkey.io/libraries/3075/41517891

  18. Dickson PE, Datta U, Wilcox TD, Auth AA, Ball RL, Dunn M, Fisher HS, Klein A, Leonardo MR, Roy TA, Saul MC, Bubier JA, Gagnon LH, Philip VM, Tarantino LM, Jentsch JD, Chesler EJ. Behavioral variation across multiple phases of intravenous cocaine self-administration among genetically diverse mouse populations. Psychopharmacology (Berl). 2026;243(6):1513-28. PMID: 40952452; PMCID: PMC13262523. https://libkey.io/libraries/3075/40952452

  19. Favours E, Tang H, Wong P, Ghilu S, Del Pozo V, Mironova E, Chen Y, Stearns T, Neuhauser S, Earley EJ, Erickson SW, Kwon JY, Jocoy EL, Groff D, Krytska K, Tsang M, Teicher BA, Mosse YP, Kolb EA, Hav M, Loo D, Houghton PJ, Bult CJ, Gorlick RG, Maris JM, Smith MA, Kurmasheva RT. Preclinical Activity of the B7-H3-Targeting Antibody-Drug Conjugate Vobramitamab Duocarmazine in Pediatric Solid Tumors. Clin Cancer Res. 2026;32(14):3031-42. PMID: 41941262; PMCID: PMC13376878. https://libkey.io/libraries/3075/41941262

  20. Iwasaki K, Carapeto P, Abarca C, Hela F, Sanjines S, Pena S, Le S, Pan H, Jackson M, Cahill C, Midha A, Diniz JA, Baker D, Domanskyi S, Espinoza S, Pena A, Cigarroa FG, Woodworth JL, Chuang JH, Garovic VD, Kirkland JL, Tchkonia T, Musi N, Kuchel GA, Robson P, Aguayo-Mazzucato C. p21-senescent cells drive pancreatic islet dysfunction through targetable paracrine signaling in type 2 diabetes. JCI Insight. 2026;11(14):e197310. PMID: 42262869. https://libkey.io/libraries/3075/42262869

  21. Smith CM, Watts B, Evans K, Kosasih H, Mayoh C, Erickson SW, Earley EJ, Neuhauser S, Stearns TM, Philip VM, Chuang JH, de Bock CE, Bowman EP, Jessen KA, Jocoy EL, Bult CJ, Teicher BA, Smith MA, Lock RB. Preclinical evaluation of the ROR1-targeting antibody-drug conjugates zilovertamab vedotin and VLS-211 against B-cell ALL patient-derived xenografts. Hemasphere. 2026;10(7):e70438. PMID: 42488471; PMCID: PMC13390736. https://libkey.io/libraries/3075/42488471

  22. Soria-Bretones I, Casas-Selves M, Samanta M, Groff D, Murray J, Fletcher JI, Farrel A, Pastor S, Patel K, Goodfellow E, Li L, Caron C, Shiwram A, Kim H, Henry D, Laterreur N, Bowlan J, Krytska K, Neuhauser SB, Stearns TM, Schubert JA, Wu J, Surrey LF, Martinez D, Mak C, Brand J, Wesley C, Somers K, Alvarez-Quilon A, Vallee F, Nejad P, Schonhoft JD, Li J, Veloso A, Young JTF, Hyer ML, Morris SJ, Mosse YP, Marshall CG, Haber M, Zimmermann M, Maris JM. The PLK4 inhibitor RP-1664 demonstrates potent efficacy in neuroblastoma preclinical models through a dual mechanism of sensitivity. Nat Commun. 2026;17(1):7531. PMID: 42288516; PMCID: PMC13408883. https://libkey.io/libraries/3075/42288516

  23. Stanton A, Aydin S, Skelly DA, McGarr T, Stavish D, Leonhard K, Taapken S, Ludwig T, McIntire E, Pankratz M, Czechanski A, Choi T, Gygi SP, Barbaric I, Vierbuchen T, Munger SC, Reinholdt LG, Pera MF. Chromosome X dosage modulates development of aneuploidy in genetically diverse mouse embryonic stem cells. Stem Cell Reports. 2026;21(7):102933. PMID: 42263679; PMCID: PMC13385727. https://libkey.io/libraries/3075/42263679

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