Antibodies are versatile tools for treating cancer, immunological disorders, and central nervous system (CNS) diseases. Developing antibody therapeutics demands sophisticated tools and deep expertise. JAX offers a suite of humanized mouse models for the evaluation of pharmacokinetics, efficacy, and safety. Trust JAX for the best models and services to accelerate your antibody discovery programs.
Translational data from PDX, cell lines, humanized CD34+/PBMC mice, and genetically engineered models.
Test optimal dosage and cytokine response based on unique PBMC profiles.
Increasingly, antibodies are being engineered to improve safety, efficacy, and clinical success. JAX provides humanized mice that support every stage of preclinical development, from PK to toxicity.
Obtain translational PK with JAX’s genetically-humanized FcRn platforms. Choose models that match your therapeutic's design and immunogenicity to refine your first-in-human dose.
Use JAX’s unrivaled NSG® mice engrafted with human PBMCs to study donor-to-donor differences and engage human-specific targets.
Select from our range of immune-humanized mouse models to ensure the right immune cell populations for your therapeutic’s mode of action. Test the safety and efficacy with or without a PDX or CDX tumor.
