dyW Physiological Data

In the dy^W strain (B6.129S1(Cg)-Lama2^tm1Eeng/J, 013786), knock-out of the laminin alpha 2 gene models merosin-deficient congenital muscular dystrophy. Homozygous dy^W mice are passive, small, and emaciated, and demonstrate partial hindleg lameness and clasping. Their muscles contain necrotic fibers with occasional areas of regeneration, and they exhibit pronounced fibrosis and increased creatine kinase (CK) activity.

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