Muscular dystrophy (MD) refers to a group of genetic neuromuscular disorders characterized by progressive skeletal muscle weakening and wasting. MD includes Duchenne Muscular Dystrophy (DMD), an X-linked progressive neuromuscular disorder caused by variants in the DMD gene that result in the dysfunction or absence of the dystrophin protein, with an incidence of 1 in 3,500 male births.
JAX offers a highly-validated collection of mouse models for neuroscience research and drug discovery, paired with expertise in developing comprehensive preclinical solutions tailored to your MD study goals. When you partner with JAX, we bring developer-based knowledge of MD mouse models and Ph.D.-level study directors to every project - delivering thoughtful, comprehensive project design and execution to your research.
See all MD Mouse Models at JAX
Common Strain Name | Phenotype | Disease Latency | Details |
|---|---|---|---|
B10 mdx |
| 3 weeks |
|
D2-mdx |
| 7 weeks |
|
mdx-4Cv |
|
| |
LGMD2A* |
|
| |
HSA-MCM FLExDUX4 |
|
|
*Cryopreserved Strain
Efficacy studies for muscular dystrophy are performed by JAX Preclinical Services Team using mouse models for the following diseases: B10.mdx and D2.mdx for DMD, DyW for Merosin-Deficient Congenital Muscular Dystrophy Type 1A (CMD1A), and A/J for dysferlinopathy.
Available tests include:
Additional mouse models and tests are available by request. Please enquire.
Consult About Your Muscular Dystrophy Study Today
| Sample Study Design | 10 mice per group |
|---|---|
| Enrollment & Baseline | Mice enrolled prior to disease onset (timing is model-specific)
|
| Serum Biomarkers | Baseline & Week 4
|
| Muscle Function* | Week 4
|
| Exercise Intolerance* | Week 4
|
Post-mortem tissue analysis is available.
*Optional readouts available for muscle function and exercise intolerance.
C57BL/10ScSn-Dmdmdx/J Strain #001801
Serum CK levels were measured to evaluate drug efficacy in reducing muscle damage. CK levels were reduced in drug-treated B10.mdx mice compared to vehicle-treated controls.
C57BL/10ScSn-Dmdmdx/J Strain #001801
Tibialis anterior sections were stained to evaluate drug efficacy on skeletal muscle fibrosis. Fibrotic area was quantified in the tibialis anterior of experimental and control mice using Sirius Red staining on histological slides.
C57BL/10ScSn-Dmdmdx/J Strain #001801
Fibrosis of Tibialis Anterior: Vehicle-treated wildtype mice show minimal fibrosis in the tibialis anterior muscle compared to vehicle-treated B10.mdx mice. Drug-treated B10.mdx mice show reduced fibrosis compared to the vehicle-treated mutants.
Access our guide to JAX Preclinical Services to learn how we can support your muscular dystrophy research. View key mouse models, details on routes of administration, behavioral and physiological assay menus, and example study designs, alongside supporting resources such as biospecimens, iPSCs, and custom model generation.
