CD34+ Humanized NSG-FLT3 Mice

Overview

The NSG-FLT3 mouse model is a comprehensive myeloid cell model following CD34 humanization. This transgenic mouse model has had the endogenous mouse Flt3 receptor knocked out and a human FLT3 ligand expressing transgene knocked in, a critical ligand for immune cell development. Human CD34 hematopoietic stem cell engrafted NSG-FLT3 mice express a diverse set of myeloid cell lineages such as CD33+ myeloid progenitors, CD14+ monocytes, and both functional CD11c+ conventional and CD123+ plasmacytoid dendritic cells. Off-the-shelf female mice are available at 18 to 24 weeks of age.

Key Benefits

• CD34+ engrafted NSG-FLT3 mice have high levels of T cells, Tregs, CD33+ myeloid cells, CD14+ monocytes, and CD56bright+/CD16- natural killer cells.
• CD34+ engrafted NSG-FLT3L mice develop functionally active CD11c+ conventional and CD123+ plasmacytoid dendritic cells.
• Readily engraftable with human cancer cell line derived and patient derived xenograft for preclinical therapeutic studies.

Research Applicatons

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