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COVID-19 Case Study

Follow a recent graduate turned lab technician as he navigates the challenges of COVID-19 diagnostic testing and explores the vital role of laboratory technicians in healthcare, while students delve into molecular biology and career opportunities in clinical labs.

Module Description

In this directed case study, students follow the story of “Marcus,” a recent college graduate who is working as a technician in a clinical laboratory to gain experience before applying to medical school. Marcus’ work duties suddenly shift when the COVID-19 pandemic hits his region to testing patient samples for the virus. Students investigate the process of COVID-19 diagnostic testing, from sample collection and processing to data analysis and the reporting of results. They then explore the molecular biology of nucleic acid purification, amplification of a target nucleic acid sequence, sequence detection and analysis, and ultimately, diagnosis. In the final section of the case, students shift their focus from technology to vocation as they research the many and varied career possibilities in a clinical laboratory and learn about the important role laboratory technicians play in the healthcare system and overall public health. Students should have prior knowledge of basic Mendelian genetic principles, DNA structure/function, and the concept of mutation. This case is appropriate for high school students in a biology, biotechnology, or allied health class.

Learning Objectives

  1. Describe the process of sample preparation and processing used to diagnose infectious diseases such as COVID-19.
  2. Analyze data to determine the presence or absence of COVID-19 infection in a patient sample.
  3. Identify at least two factors that distinguish a clinical diagnostic laboratory from a research laboratory.
  4. Discuss the training and credentials required to work as a laboratory technician in a clinical diagnostic laboratory.
  5. Compare gene sequences to uncover if individuals carry a gene variant associated with hereditary skin cancer.
  6. Describe how laboratory technicians contribute to the healthcare system and what role they play in contributing to human health.

NGSS Alignments

Disciplinary Core Ideas
  • LS3.A Inheritance of Traits
  • LS1.A Structure and Function
Cross Cutting Concepts
  • Patterns
  • Cause and Effect
  • Structure and Function
Science & Engineering Practices
  • Constructing Explanations and Designing Solutions
  • Using Mathematics and Computational Thinking
  • Analyzing and Interpreting Data
  • Obtaining, Evaluating, and Communicating Information

Teacher Resources

Online Course
NSTA COVID-19 Case Study Resources

Download

Student Activities

Online Course
NSTA The Power of a Test: COVID-19 Case Study

View case study

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