Cataracts

Lse

Low set ear; vascular hazy cornea, homozygotes have cataracts, AD

7

nm1863

Cataract, abnormal iris and cornea, AR

12

wa3

Waved 3, mice have wavy coat, eyelids fail to develop and have an enlarged heart and esophagus, AR

12

eyeless

Strain with anophthalmos in 80% of offspring. Mice with intact globes have micro-ophthalmia and frequently congenital corneal perforations, with collapse of the anterior chamber, AR

3

A/J

Crystal deposits in iris, XR

X

Nm2557

X-linked model for aniridia: heterozygous females have a small iris, homozygous females and males have a cataract, XD

X

nm2619

Mouse model for PHPV, AR

9

DBA/2J

Pigmentary glaucoma model, with essential iris atrophy with subsequent angle clogging with pigment. Mice develop bupthalmos and progressively enlarged optic cups. At least two recessive genes are involved [Chang, 1999]

gene #1 ipdiris pigment dispersion, AR

6

gene #2 isa iris stromal atrophy, AR

4

nm2702

swollen eyes, inner retina loss, ON cupping , AR

11

AD=autosomal dominant, AR=autosomal recessive, XD=X-linked Dominant, XR=X-linked recessive