The West Lab

Mitochondria are multifaceted organelles integral to many cellular processes including energy generation and programmed cell death. More recently, mitochondria have emerged as central hubs in the mammalian immune system, orchestrating signal transduction cascades and metabolic switches necessary for the activation and survival of immune cells. Mitochondria are also important sources of damage-associated molecular patterns (DAMPs), which can trigger inflammatory responses when released from the organelle. Given their pleiotropic roles, mitochondrial dysfunction is increasingly implicated as a cause or accelerant of numerous human diseases.

Research in the West Lab aims to: 1) define how mitochondria function as central regulators of innate immune and inflammatory responses, and 2) delineate how the mitochondrial-innate immune axis contributes to disease pathobiology.We pursue a multidisciplinary approach by integrating immunology, cell biology, and physiology using engineered mouse models of disease, multi-omics,flow cytometry, and super-resolution imaging.