The Rosenthal Lab

The Rosenthal Lab uses mammalian genetics to explore the the role of growth factors, stem cells and the immune system in the development and regeneration of heart and skeletal muscle. Our recent research uses mouse genetic diversity panels to investigate the role of aging, cellular interactions and the immune system in cardiovascular disease and repair. Genetic mapping reveals distinct spectra of cell composition and response in regenerative scenarios, demonstrating how background genetics can either facilitate or prevent tissue repair. In our infectious disease research, we have recently created more precise mouse models for SARS-CoV-2, using them to examine the role of host genetics in susceptibility and disease course. This work was published in Nature Communications.