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Jennifer Trowbridge, Ph.D.

Professor, The Dattels Family Chair

Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.

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Location

Bar Harbor, ME

Contact

207-288-6183
[email protected]

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The Trowbridge laboratory studies cell fate regulation within the hematopoietic system. Our current focus is on the epigenetic regulation of hematopoietic stem cell (HSC) and progenitor cell lineage commitment in three contexts: (1) normal blood development and maintenance, (2) alterations that occur during the process of aging, and (3) alterations that occur during the process of transformation giving rise to leukemia. Our ultimate goal is to reveal epigenetic patterns and processes that are uniquely deregulated during aging and/or transformation, which can be used to identify novel biomarkers of disease and targets for development of therapeutics.

Podcasts featuring Professor Trowbridge:

Selected Publications

View full list of publications

Selected Publications

  • Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation. 
    Khokhar ES, Borikar S, Eudy E, Stearns T, Young K, Trowbridge JJ.
    Exp Hematol. 2020 Feb;82:43-52.e4. doi: 10.1016/j.exphem.2020.01.014. Epub 2020 Feb 1.
    PMID: 32014431 Free PMC article. 

  • Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging.
    Young K, Eudy E, Bell R, Loberg MA, Stearns T, Sharma D, Velten L, Haas S, Filippi MD, Trowbridge JJ.
    Cell Stem Cell. 2021 Aug 5;28(8):1473-1482.e7. doi: 10.1016/j.stem.2021.03.017.
    Epub 2021 Apr 12.
    PMID: 33848471

  • Hand in hand: intrinsic and extrinsic drivers of aging and clonal hematopoiesis. 
    SanMiguel JM, Young K, Trowbridge JJ.
    Exp Hematol. 2020 Nov;91:1-9. doi: 10.1016/j.exphem.2020.09.197. Epub 2020 Sep 28.
    PMID: 32991978 Free PMC article. Review. 

  • Heritable genetic background alters survival and phenotype of Mll-AF9-induced leukemias. 
    Young K, Loberg MA, Eudy E, Schwartz LS, Mujica KD, Trowbridge JJ.
    Exp Hematol. 2020 Sep;89:61-67.e3. doi: 10.1016/j.exphem.2020.07.012. Epub 2020 Aug 6.
    PMID: 32768438 Free PMC article. 

  • Sequentially inducible mouse models reveal that Npm1 mutation causes malignant transformation of Dnmt3a-mutant clonal hematopoiesis. 
    Loberg MA, Bell RK, Goodwin LO, Eudy E, Miles LA, SanMiguel JM, Young K, Bergstrom DE, Levine RL, Schneider RK, Trowbridge JJ.
    Leukemia. 2019 Jul;33(7):1635-1649. doi: 10.1038/s41375-018-0368-6. Epub 2019 Jan 28.
    PMID: 30692594 Free PMC article. 

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