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Comparison of Widely Used JAX Mice for Type 2 Diabetes and Obesity

This table compares the major type 2 diabetes and obesity phenotypes among humans and key models.

Diabetes Phenotype

Phenotypes	Humans	B6.Cg-Lep^ob/J (000632) B6.BKS(D)-Leprdb/J (000697)	BKS.Cg-Dock7^m +/+ Lepr^db/J (000642)	C57BL/6J DIO (000664)	TALLYHO/JngJ (005314)	KK.Cg-A^y/J (002468)	NEW! MSNASH/PcoJ (030888)
Induced or spontaneous	Spontaneous	Spontaneous	Spontaneous	Diet-induced	Spontaneous	Spontaneous	Spontaneous
Genetics	Polygenic	Polygenic	Polygenic	Polygenic	Polygenic	Polygenic	Polygenic
Onset	Mature (progressive)	Young	Young	Mature	Mature	Mature	Mature
Sex	M, F	M, F	M, F	M	M	M, F	M
Hyperinsulinemia	Moderate	Severe	Moderate (transient)	Mild	Yes	Severe	Yes
Glucose intolerance	Yes	Yes	Yes	Yes	Yes	Yes	Yes
Hyperglycemia	Yes	Moderate (transient)	Severe	Mild / Moderate	Yes	Yes	Moderate
Islet atrophy	Variable	No (hyperplasia only)	Yes	No	Yes (late onset)	Hypertrophy	Unknown
Impaired wound healing	Yes	Yes	Yes	Yes	Unknown	Unknown	Unknown
Nephropathy	Yes	No	Yes (mild)	No	Unknown	Yes	Unknown

Obesity Phenotypes

Phenotypes	Humans	B6.Cg-Lep^ob/J (000632) B6.BKS(D)-Leprdb/J ( 000697)	BKS.Cg-Dock7^m +/+ Lepr^db/J (000642)	C57BL/6J DIO (000664)	TALLYHO/JngJ (005314)	KK.Cg-A^y/J (002468)	NEW! MSNASH/PcoJ (030888)
Induced or spontaneous	Spontaneous	Spontaneous	Spontaneous	Diet-induced	Spontaneous	Spontaneous	Spontaneous
Genetics	Polygenic	Monogenic	Monogenic	Polygenic	Polygenic	Monogenic	Polygenic
Onset	Variable	Young	Young	Mature	Juvenile	Mature	Young
Sex	M, F	M, F	M, F	M	M, F	M, F	M
Degree	Moderate	Severe	Severe	Severe	Moderate	Moderate	Moderate
Hypertriglyceridemia	Yes	Yes	Yes	Mild	Yes	Yes	Yes
Leptin/leptin receptor axis	Normal	Disrupted	Disrupted	Normal	Normal	Normal	Intact
Hyperphagia	No	Yes	Yes	Mild	No	Yes	No
Hypercorticism	No	Yes	Yes	No	Unknown	No	Unknown
Thermoregulatory defects	No	Yes	Yes	Unknown	No	Unknown	No
Liver steatosis	Variable	Severe	Severe	Unknown	Moderate	Moderate	Diet-induced

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