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JAX Frontend Platform

Model-AD Consortium

Model organism development and evaluation for late-onset Alzheimer's Disease.

The MODEL-AD consortium consisting of a Center at Indiana University School of Medicine, The Jackson Laboratory, Sage Bionetworks and the University of Pittsburgh School of Medicine, and a Center at the University of California Irvine has been established by the National Institute on Aging to:

  • Develop the next generation of in vivo AD models based on human data
  • Institute a standardized and rigorous process for characterization of animal models
  • Align the pathophysiological features of AD models with corresponding stages of clinical disease using translatable biomarkers
  • Establish guidelines for rigorous preclinical testing in animal models
  • Ensure rapid availability of animal models, protocols and validation data to all researchers for preclinical drug development

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News and Announcements

Leveraging Model & Data Resources to Advance Alzheimer’s and Dementia Discovery Program

Leveraging Model & Data Resources to Advance Alzheimer’s and Dementia Discovery Program

Get information and resources for Alzheimer's and other dementias from the Alzheimer's Association.

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Cornucopia: LOADs of New Mouse Models Available

Cornucopia: LOADs of New Mouse Models Available

Alzheimer’s researchers have long wished for better mouse models. That is now coming true. Scientists at the Jackson Laboratory in Bar Harbor, Maine, are cranking out numerous lines that express humanized Aβ and tau in combination …

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MODEL-AD drives progress for Alzheimer’s research

MODEL-AD drives progress for Alzheimer’s research

The July issue of Alzheimer’s & Dementia spotlights progress by MODEL-AD and its work to create better models for Alzheimer’s disease research and catalyze progress in the field.

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New analysis - targeted Alzheimer’s research and drug discovery

New analysis - targeted Alzheimer’s research and drug discovery

Researchers at The Jackson Laboratory offer the first comprehensive ranking of the relative role and significance of every known gene and protein in the development of Alzheimer’s Disease in advance of the Alzheimer's Association International Conference, July 28

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Researchers are closing in on a mouse model for late-onset Alzheimer’s research

Researchers are closing in on a mouse model for late-onset Alzheimer’s research

Mice don’t get Alzheimer’s—and while that’s good news for mice, it’s a big problem for biomedical researchers seeking to understand the disease and test new treatments. Now, researchers at The Jackson Laboratory are working to create the first strain of mice that’s genetically susceptible to late-onset Alzheimer’s, with potentially transformative implications for dementia research.

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JAX and LG AI Research partner to pioneer biomedical advancements

JAX and LG AI Research partner to pioneer biomedical advancements

Two world-leading organizations are partnering to further expand AI capabilities in biomedical science and catalyze medical progress.

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Gene Expression Database for Mouse Development named a Global Core Biodata Resource

Gene Expression Database for Mouse Development named a Global Core Biodata Resource

The Gene Expression Database for Mouse Development has been named a Global Core Biodata Resource in the 2023 selection round.

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JAX's 2023 achievements

JAX's 2023 achievements

JAX is celebrating important research breakthroughs, new faculty and leadership appointments, and crucial advancements in legislation.

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Advancing Alzheimer's disease research

Advancing Alzheimer's disease research

To solve Alzheimer’s disease, JAX's Kristen O'Connell is working to understand the biological factors that cause it.

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Applying AI and machine learning to complex research tasks

Applying AI and machine learning to complex research tasks

JAX researchers are at the forefront of developing and implementing AI-based technologies for a variety of research applications.

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