Cytogenetic and Down Syndrome Models Resource

A team led by David Serreze presents a mouse model for studying severe immune checkpoint inhibition-based damage to heart and skeletal muscle, providing an important resource for maximizing the benefits and minimizing the side effects of vital immunotherapies.

JAX scientists are working to make it more feasible for researchers to incorporate diverse background genetics to better model human disease in mice.

A new protocol sets the stage for researchers to directly compare mouse and human cells, and readily incorporates genetic diversity into mouse-based research to more closely approximate human health conditions.

Using KOMP2, JAX researchers have now generated and characterized more than 2,000 knockout mice, gaining important insights into mammalian genetics and potential health impacts.

Two world-leading organizations are partnering to further expand AI capabilities in biomedical science and catalyze medical progress.

JAX researchers have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. This will allow scientists to model patient variation in COVID-19 outcome.

New research finds that the epigenetic landscape is highly variable between the strains of Diversity Outbred mice and is associated with variation in gene expression.

James Godwin has received a a five-year, $2.4M R01 grant to investigate regeneration in model organisms, and his work with mice so far has shown that multiple immune-cell types inhibit tissue regeneration.