Improved animal models of Parkinsonism are essential to advance our understanding of disease pathophysiology and for eventual testing of potential therapeutics. To that end, the Michael J. Fox Foundation for Parkinson’s Research has funded the generation, characterization and distribution of animal models of Parkinsonism as part of its strategy to provide preclinical tools to the research and drug development community.
We are currently characterizing novel models side-by-side with some of the more prominent existing mouse models of PD. Unlike most PD models developed to date, these will be available to pharmaceutical and biotechnology companies for use to develop and test potential therapies. Also available are "research tool" strains including transgenics that express marker genes in affected brain regions, and strains with systems for regulating gene expression (e.g. Cre recombinase and tet-inducible promoters) in specific types of neurons.
The Parkinson’s Disease Mouse Model Resource at the Jackson Laboratory is made possible by support from the Michael J. Fox Foundation for Parkinson’s Research.
The Mutant Mouse Resource and Research Center (MMRRC) distributes and cryopreserves scientifically valuable, genetically engineered mouse strains and mouse ES cell lines with potential value for the genetics and biomedical research community.
The Jackson Laboratory maintains and distributes chromosome-aberration stocks that provide mouse models for Down syndrome, as well as the study of chromosomal aneuploidy.
For over half a century Oak Ridge National Laboratory generated and maintained a diverse collection of mouse stocks.
The services and collections of the Joan Staats Library support The Jackson Laboratory's mission to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
ATAC-seq is a new protocol to capture open chromatin sites by performing adaptor ligation and fragmentation of open chromatin regions.
NOD-scid IL2rgnull (NSG) and NOD-Rag1null IL2rgnull (NRG) mice support heightened levels of engraftment with human cells and tissues.
The Mouse Models of Human Cancer Database (formerly, the Mouse Tumor Biology Database) supports the use of the mouse as a model system of human cancers by providing access to information and data.
The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products across databases.
A comprehensive resource providing mouse models for facial, dental, eye, ear and skull development research, as well as mouse models of human craniofacial syndromes such as cleft palate.
The JAX Cre Repository's aim is to provide the scientific community with a centralized, comprehensive set of well-characterized Cre Driver lines and related information resources.
Tools for automatic glomerulus identification and histological quantification from scanned PAS slides.
Describes mouse models for ocular research available at The Jackson Laboratory and provides a list of known mouse mutations that affect vision.
GRS supplies the scientific community with the most comprehensive collection of mouse genetic resources and mouse-related technologies, such as ES cells and tool strains.
International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.
The IMSR is a searchable online database of mouse strains, stocks, and mutant ES cell lines available worldwide, including inbred, mutant, and genetically engineered strains.
KOMP provides critical tools for understanding gene function and the genetic causes of human diseases.
The SMSR maintains mice that are important tools for genetic analysis of complex diseases, including consomic strains.
The Mouse Mutant Resource is identifying causative mutations and associated genes that underlie rare phenotypic anomalies, and are able to further annotate the mammalian genome, assigning physiological functions to genes for which no role has previously been identified.
MouseMine is a powerful new system for online access to mouse data from MGI (Mouse Genome Informatics).
Serves as a centralized resource for mouse models and tools that have been validated for use in preclinical studies of peripheral neuropathy.
We offer a growing number of mouse lines expressing proteins that activate, inhibit or detect neuronal activity.
The WORM Human OrthoLogy Explorer is a meta-tool that uses machine learning to predict novel least diverged orthologs (LDOs).
