STZ-Induced Diabetes

Streptozotocin (STZ) is an alkylating agent that targets insulin-producing beta cells in the pancreas, mimicking Type 1 diabetes phenotypes in mice. Propel your preclinical research using on-demand STZ-injected models generated on various genetic backgrounds, as well as additional services available to researchers worldwide.

Key benefits

• Diabetes is induced in C57BL/6J, NOD-scid, and NSG male mice using validated protocols
• No need to handle STZ: we safely dispose of the harmful chemical and only provide mice with non-fasting blood glucose exceeding 250 mg/dL

Capabilities

• Diabetic mice are available at 7-9 weeks of age
• Customizable options using other JAX strains, different doses, and more, after our feasibility assessment
• Outbred J:ARC(S) males respond to STZ with the highest blood glucose of any strain tested to date
• Diabetes can be induced in nude mice, including outbred J:NU males and inbred NU/J males & females
• We can also inject neonatal C57BL/6J pups for non-alcoholic steatohepatitis (NASH) research and other projects
• Diabetes modeling can be integrated with Efficacy Testing Services and histology services as needed

STZ Induction Statistics^a

^a Non-fasting glucose was measured 14-16 days after the first injection. Data are for guidance only.

Additional phenotypic data from STZ-induced C57BL/6J, NOD scid, and NSG mice:

STZ-Induced
Diabetes: FAQ

Phenotypes of STZ
Mice

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