A syngeneic mouse model, also known as an allograft mouse tumor system, provides an effective approach for studying how cancer therapies perform in the presence of a functional immune system.
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A syngeneic mouse model, also known as an allograft mouse tumor system, provides an effective approach for studying how cancer therapies perform in the presence of a functional immune system.
Cancer immunotherapies work with a patient’s own immune system to increase native anti-tumor responses. In the development of these drugs, conventional patient-derived xenograft (PDX) models lack relevance due to the animals’ immunocompromised status.
Syngeneic mouse models, however, consist of tumor tissues from the same genetic background as the given immuno-competent mouse strain. A syngeneic mouse model provides an effective approach for studying how cancer therapies perform in the presence of a functional immune system.
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