NSG-Tg(Hu-IL15); NSG Flt3KO hFLT3LG Tg mice combine the features of the highly immunodeficient NOD scid gamma (NSG&trade;) mouse (Stock No. <a href="https://www.jax.org/strain/005557" target="_blank">005557</a>) with a transgene expressing human FLT3LG (fms related receptor tyrosine kinase 3 ligand), a knock-out of its receptor Flt3 (Flt3 interacting zinc finger protein 1), and a human IL15 transgene that enhances the development of human NK cells in immunodeficient mice engrafted with human stem cells. This model enables the engraftment of diverse hematopoietic lineages, useful for immuno-oncology, immunology, and infectious disease studies. (<a href="https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/most-popular-jax-mice-strains/nsg-flt3-il15">See representative engraftment data</a>) SPF (specific pathogen-free) conditions are recommended. Please see our <a href="https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/nsg-portfolio/housing-and-breeding-considerations-for-nsg-mice" target="_blank">NSG housing and breeding</a> information for additional details. View our <a href="https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/nsg-portfolio">Resources for the NSG&trade; mouse model</a>, including: <ul><li>NSG&trade; Mouse Model Portfolio</li><li>Housing and Breeding Considerations for NSG&trade; Mice</li><li>Frequently Asked NSG&trade; Questions</li><li>Breakthrough Research Using NSG&trade;</li><li>Immunodeficient Mouse and Xenograft Host Comparisons</li><li>Flow Cytometry Characterization Data for Immunodeficient JAX Strains</li></ul>

The use of this mouse model is subject to the terms and conditions of the Limited Use Label License from Caribou Biosciences, Inc.

The use of this mouse strain or other product (the "Licensed Product") is subject to the terms and conditions of the Limited License from The Broad Institute.

Use of MICE by companies or for-profit entities requires a no-fee JAX Leap License prior to shipping.

NSG-Tg(Hu-IL15); NSG Flt3KO hFLT3LG Tg mice combine the features of the highly immunodeficient NOD scid gamma (NSG&trade;) mouse (Stock No. <a href="https://www.jax.org/strain/005557" target="_blank">005557</a>) with a transgene expressing human FLT3LG (fms related receptor tyrosine kinase 3 ligand), a knock-out of its receptor Flt3 (Flt3 interacting zinc finger protein 1), and a human IL15 transgene that enhances the development of human NK cells in immunodeficient mice engrafted with human stem cells. This model enables the engraftment of diverse hematopoietic lineages including T cells, mature NK cells, myeloid cells, and dendritic cells. (<a href="https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice/most-popular-jax-mice-strains/nsg-flt3-il15">See representative engraftment data</a>) CD34+ humanized NSG-FLT3-IL15 (Stock No. 703722) mice can be ordered on our <a href="https://www.jax.org/jax-mice-and-services/preclinical-research-services/humanized-mice/humanized-mice-form">humanized mouse order form</a>.

Ask <a target="_blank" href="https://www.jax.org/jax-mice-and-services/customer-support" rel="noreferrer">customer service</a> for an anticipated lead time

NOD.Cg-Flt3<em2Mvw> Prkdc<scid> Il2rg<tm1Wjl> Tg(FLT3LG)7Sz

Homozygous for Flt3<em2Mvw>, Homozygous for Prkdc<scid>, Homozygous for Il2rg<tm1Wjl>, Homozygous for Tg(FLT3LG)7Sz, Homozygous for Tg(IL15)1Sz

Homozygous for Flt3<em2Mvw>, Homozygous for Prkdc<scid>, Hemizygous for Il2rg<tm1Wjl>, Homozygous for Tg(FLT3LG)7Sz, Homozygous for Tg(IL15)1Sz